ABC transporters in microorganisms research, innovation and value as targets against drug resistance by Alicia Ponte-Sucre

Cover of: ABC transporters in microorganisms | Alicia Ponte-Sucre

Published by Caister Academic in Norfolk, UK .

Written in English

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Edition Notes

Includes bibliographical references and index.

Book details

Statementedited by Alicia Ponte-Sucre
Classifications
LC ClassificationsQP552.A87 A345 2009
The Physical Object
Paginationxii, 260 p., 10 p. of plates :
Number of Pages260
ID Numbers
Open LibraryOL24537143M
ISBN 101904455492
ISBN 109781904455493
LC Control Number2009499924
OCLC/WorldCa339979690

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The topics include the structure, physiology, and evolution of ABC transporters, as well as their special characteristics in specific microorganisms, including bacteria, yeast, trypanosomes, and malaria parasites.

In particular, the book describes the most recent research and innovations relative to the role of ABC transporters in the design of. The topics include the structure, physiology and evolution of ABC transporters, and their special characteristics in bacteria, yeast, trypanosomes and malaria parasites.

The book covers the most recent research into the role of ABC transporters in the design of strategies to circumvent drug resistance. Each chapter comprises an exhaustive review of the particular topic from both the scientific.

ABC Transporters - a Smart Example of Molecular Machineries 1 Thorsten Jumpertz, I. Barry Holland and Lutz Schmitt Evolution and Function of the Multi-drug Resistance-Iinked ABC Transporters in Bacteria and Cancer Cells 35 Zuben E.

Sauna and Suresh V. Ambudkar Stmcture-Function Relationships in ABC Multidrug Transporters Further, the bacteriocin ABC transporter showed antimicrobial activity against food spoilage microorganisms. Conclusions The ABC transporter ATP-binding protein could.

In particular the book describes the most recent research and innovations relative to the role of ABC transporters in the design of strategies to circumvent drug resistance in microorganisms. Each chapter comprises an exhaustive review of the particular topic and provides insights into the future of the field both from the scientific and.

ABC Transporters in Microorganisms Research, Innovation and Value as Targets against Drug Resistance Edited by: Alicia Ponte-Sucre Universidad Central de Venezuela, Caracas, Venezuela Published: August Pages: xii + ISBN: Book: £, $ Published by: Caister Academic Press ABC transporters: from microorganisms to man.

ABC transporters: from microorganisms to man. ABC transporters: from microorganisms to man Annu Rev Cell Biol.

; doi: / Author C F Higgins 1 Affiliation 1. Summarize the function of the three major ABC transporter categories: in prokaryotes, in gram-negative bacteria and the subgroup of ABC proteins ATP-binding cassette transporters (ABC-transporters) are members of a protein superfamily that is one of the largest and most ancient families with representatives in all extant phyla from prokaryotes.

The superfamily of ABC-transporters comprises one of the most abundant protein families in nature. These transporters are believed to date back in evolutionary time more than 3 billion years and are distributed in all three kingdoms of living organisms, archaea, eubacteria, and a are a unique group of microorganisms classified as bacteria (Archaeobacteria).

Goffeau, B. De Hertogh, in Encyclopedia of Biological Chemistry (Second Edition), Function and Diseases. The ABC transporters from Archaea, Gram-negative, and Gram-positive plasma membranes are widely different in their organization and composition.

The variety of substrates transported: sugars, amino acids, lipids, ions, polysaccharides, peptides, proteins, toxins, drugs, antibiotics. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms.

This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. ABC transporters in microorganisms book superfamily of ABC-transporters comprises one of the most abundant protein families in nature.

These transporters are believed to date back in evolutionary time more than 3 billion years and are distributed in all three kingdoms of living organisms, archaea, eubacteria, and -transporters have to be distinguished from ABC-proteins.

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene is represented in all extant phyla, from prokaryotes to humans. ABC transporters often consist ABC transporters in microorganisms book multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases.

One example is the ABC system, which utilizes ATP-Binding Cassette transporters. Each ABC transporter is composed of three different components: 1) membrane-spanning proteins that form a pore across the cell membrane (i.e.

carrier protein), 2) an ATP binding region that hydrolyzes ATP, providing the energy for the passage across the membrane. SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living organisms and function in many different aspects of bacterial physiology.

ABC transporters are best known for their role in the import of essential nutrients and the export of toxic molecules, but they can also mediate the transport of many other physiological substrates.

This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins.

The first ABC transporter was discovered in and was named P. ABC transporters constitute one of the largest protein families found in all living organisms.

ABC transporters are driven by ATP hydrolysis and can act as exporters as well as importers. The plant genome encodes for more than ABC transporters, largely exceeding that of other organisms. In Arabidopsis, only 22 out of have been functionally analyzed.

They are localized in most. ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications.

ABC-transporters: implications on drug resistance from microorganisms to human cancers. Lage H(1). Author information: (1)Institute of Pathology, Humboldt-University Berlin, Charité Campus Mitte, Schumannstrasse 20/21, D Berlin, Germany. @   This book provides new structural, biochemical, and clinical information on ABC transporters.

The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins.

The first ABC transporter was discovered in and was named P-glycoprotein. Mammalian ABC Transporters in Health and Disease P. Borst and R. Oude Elferink Annual Review of Biochemistry ATP-Binding Cassette Transporters in Bacteria Amy L.

Davidson and Jue Chen Annual Review of Biochemistry EVOLUTION OF THE ATP-BINDING CASSETTE (ABC) TRANSPORTER SUPERFAMILY IN VERTEBRATES Michael Dean and Tarmo Annilo.

ABC transporters are driven by ATP hydrolysis and can act as exporters as well as importers. The plant genome encodes for more than ABC transporters, largely exceeding that of other organisms. ABC‐type transporters in bacteria.

Bacterial ABC transporters responsible for antibiotic resistance. Implications of ABC transporters in antimicrobial. The ATP-binding cassette (ABC) transporter systems are a conserved superfamily of multisubunit permeases that are found in all living organisms.

Bacterial ABC transporters can be either importers or exporters. The ABC proteins form the largest paralogous family of proteins in Escherichia coli. It was initially predicted as a daunorubicin exporter on the basis of its similarity to the drrAB.

ABC Transport Plc commenced operation in road passenger transportation on Febru as an off-shoot of Rapido Ventures with a view to running a modern road transportation system in Nigeria. In MarchCapital Alliance Private Equity (CAPE) acquired 30% shares of ABC Transport.

This book is devoted to the fascinating superfamily of plant ATP-binding cassette (ABC) transporters and their variety of transported substrates. It highlights their exciting biological functions, covering aspects ranging from cellular detoxification, through development, to symbiosis and defense.

Purchase ABC Proteins - 1st Edition. Print Book & E-Book. ISBNABC transporters use the energy of ATP hydrolysis to transport substrates across cell membranes. Bacterial ABC transporters are essential in cell viability, virulence, and pathogenicity.

The substrates that can be transported include ions, amino acids, peptides. Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in cholesterol homeostasis, blood pressure regulation, endothelial function, vascular inflammation, as well as platelet production and aggregation.

In this regard, ABC transporters, such as ABCA1, ABCG5 and ABCG8, were. the first complete ABC transporter to have its high resolution ( Å) structure determined in the physiological assembly, and it has yielded valuable insight into how ABC transporters work (Locher et al.

All ABC transporters contain two membrane-spanning domains that harbor a translocation pathway for a specific substrate. The operon structure is frequently found for the genes of three molecular components: the ATP-binding protein, the membrane protein, and the substrate-binding protein.

Here, we developed an "ortholog group table" by comparison and classification of known and putative ABC transporters in the complete genomes of seven microorganisms.

ABC Transporters: From Microorganisms to Man ABC Transporters: From Microorganisms to Man Higgins, C F All cells and subcellular compartments are separated from the external milieu by lipid membranes.

Cell survival requires the regulated and selective passage /92/ 1 $ HIGGINS of specific molecules across these membranes, not only to acquire. ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date.

It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings.

This book is sure to become a classic and will. Cell Structure of Bacteria, Archaea, and Eukaryotes Overview of Prokaryotic and Eukaryotic Cells; The Cytoplasmic Membrane of Prokaryotic and Eukaryotic Cells; Transport Across the Cell Membrane; Cell Walls of Prokaryotes; Specialized External Structures of Prokaryotes; Specialized Internal Structures of.

A big question. I will focus on a brief overview of the structure and function of ABC transporters, and leave the details of proposed mechanisms for a different day and a different answer. Intro All organisms depend on membrane transport, whether. *These authors contributed equally to this book chapter ABC transporters constitute one of the largest protein families found in all living organisms.

ABC transporters are driven by ATP hydrolysis and can act as exporters as well as importers. The plant genome encodes for more than ABC transporters, largely exceeding that of other organisms. By contrast, in bacteria and archaea, ABC transporters generally have one or more SBPs in addition to permeases and ATPases, and function predominantly in uptake of molecules as opposed to efflux [9, 10].

ABC transporters transport molecules against a chemical gradient driven by free energy change associated with ATP hydrolysis. ABC transporters have been identified in organisms belonging to each of the three major domains (bacteria, archaea and eukarya, including man), and might thus be considered as an ancient proteinaceous device for solutes to pass a lipid bilayer against a concentration gradient.

Keywords:multidrug resistance, lactococcus lactis, lactobacillus brevis, antibiotic resistance, excretion, secondary transporters, abc-transporters Abstract: Gram-positive lactic acid bacteria possess several Multi-Drug Resistance systems (MDRs) that excrete out of the cell a wide variety of mainly cationic lipophilic cytotoxic compounds as.

The majority of described MDR transporters in bacteria use ion motive force, while only a few systems have been shown to rely on ATP hydrolysis.

However, recent reports on MDR proteins from gram-positive organisms, as well as genome analysis, indicate that the role of ABC-type MDR transporters in bacterial drug resistance might be underestimated. ABC transporters, mechanisms and biology: an overview / I. Barry Holland --Natural history of ABC systems: not only transporters / Elie Dassa --Structure of ABC transporters / Joseph K.

Zolnerciks [and others] --Catalytic and transport cycles of ABC exporters / Marwan K. Al-Shawi --ABC solute importers in bacteria / Jinming Cui, Amy L. Davidson.The ABC family of multidrug transporters in microorganisms van Veen, H. W. & Konings, W.

N., Jun, In: Biochimica et Biophysica Acta., p. 31 - 36 6 p. Research output: Contribution to journal › Article › Academic › peer-review.Features over superb illustrations including algae, molds, bacteria, protozoa, and viruses; Emphasizes the beneficial role of microorganisms everywhere in the natural world, from oceans to the child's own body; Communicates the usefulness of microorganisms by relating them to children's everyday experiences, from eating yogurt to taking Reviews: 8.

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